The umbilical cord stem cells could be useful in treating rheumatoid arthritis, according to a People's Hospital of Peking University in China published in the journal Arthritis Research and Therapy.
Researchers show through in vitro experiments and animal mesenchymal stem cells (MSCs) in cord blood suppress inflammation and attenuate collagen-induced arthritis.
Explains Zhan-guo Li, author of the study, "the CMM can have a profound immunosuppression, which encourages their use in the treatment of autoimmune diseases such as rheumatoid arthritis. Currently, the most common source of MSCs is the bone bone. However, the bone marrow aspiration is an invasive procedure and the number and differentiation potential of MSCs from bone marrow decreases with age. In contrast, the collection of umbilical cord CMM does not require any invasive procedure. "
The researchers took immune cells from patients with rheumatoid arthritis showed that umbilical MSCs were able to suppress cell proliferation, invasive behavior and inflammatory responses. Systemic infusion of umbilical MSCs in mice significantly reduced the severity of collagen-induced arthritis. "Rheumatoid arthritis inflicts a huge cost to health services around the world and none of the existing agents get a long-term remission that allows to stop using drugs. Therefore, a new and more effective therapy for rheumatoid arthritis will very welcome, "Li concluded.
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